Cyber technologies have already changed our lives drastically. Nearly every area of social relations is currently being digitalized both nationally and internationally. The UN Security Council, in its resolutions 2419 (2018), 2462 (2019), and 2490 (2019), and many others, recognizes that the activity of individuals and non-state entities in the cyber area may constitute a threat to international peace and security. Cyber attacks on critical infrastructure; the impossibility to use online payment systems; blocking access to the Internet, Twitter and Instagram accounts, Zoom and other services; and the application of cyber measures in response to cyber threats and many others have started to be actively discussed today with regard to the problem of sanctions. This chapter seeks to provide an overview of developments and situations, when the application of sanctions is affected by the development of cyber means. It also focuses on the changes in and legal qualifications for the grounds, subjects, targets, means and methods of introduction and implementation of sanctions regimes in the digital age.