The United States initiated the sanctions on Iran without considering international deals and agreements such as the Joint Comprehensive Plan of Action (JCPOA). Now, an array of restrictions is imposed on banking, shipping, trade, oil, and aircraft industries on Iran. The main objective of economic sanctions is the countries’ economies. These sanctions have some negative consequences on the economy of each country, at least in the short term inevitably. Sanctions could cause a fall in national revenues and earnings (especially for Iran, which largely relies on oil exports), and an increase in prices, unemployment, and inflation rate.These are the direct objectives of sanctions, but sanctions have many other indirect, adverse, or maybe unwanted effects on population welfare and health. Economic sanctions affect all things that are related to economic situations such as population health. Health services in Iran are mainly provided by the public sector which in turn relies on government revenues that are reduced due to sanctions. From the viewpoint of social determinants of health (SDH), economic sanctions have an impact on all three elements of the SDH framework, including socio-economic-political context, structural determinants, and intermediary determinant that lead to negative impacts on equity in health and wellbeing.