In the light of geopolitical conflicts and instability, sanctions play an important role in the international economic policy debate - especially against countries such as Russia, Iran and China. Economic sanctions are often intended to achieve foreign and security policy goals: fighting terrorism, protecting democracy and human rights, or resolving conflicts. In this issue of EconPol Forum, our authors examine, using the evidence-based studies, the extent to which various sanctions have achieved their goals. How do they affect economic growth, trade, and prosperity? In addition, we want to understand their impact on sectoral development of agriculture, energy and mining, as well as on human rights, military spending or life expectancy. In this context, international trade, financial transactions, technology transfer and other economic activities, among others, are systematically studied. And researchers look at different types of sanctions, such as unilateral, multilateral, and extraterritorial. We shed light on the major and immediate challenges for target countries and sender countries. And our authors examine implications for other regions. At the same time, they make a critical assessment of past sanctions strategies and experiences. They offer some suggestions on how policymakers can make sanctions more effective in the future.