Just as U.S. policy should end our endless wars, sanctions as part of protracted war — as in Iraq and Afghanistan — or sanctions that make war on general populations should also end. Whoever wins the presidency in November must rethink how sanctions can be an essential, yet prudent, tool of U.S. economic statecraft. Such a reformulation should rely on lessons learned from sanctions research and include reconstructing the U.S. government vision and architecture for sanctions policy.